DOSAGE AND ADMINISTRATION

1.1 Erectile Dysfunction
5.3 Prolonged Erection
5.5 Sudden Hearing Loss
17.8 Sudden Hearing Loss
7.2 Potential for Other Drugs to Affect CIALIS
2.4 CIALIS for Once Daily Use for Erectile Dysfunction and Benign Prostatic Hyperplasia

Aachen, Germany, 2 June 2025 – Grünenthal today announced the acquisition of the commercial rights to Cialis® (tadalafil) in Mexico, Brazil and Colombia from Eli Lilly and Company. Over the next few years, Grünenthal and Lilly will work together to transfer the manufacturing to Grünenthal's production site in Santiago, Chile, that will supply Cialis® for Mexico, Brazil and Colombia moving forward. The transaction is expected to close in the third quarter of 2025, subject to the satisfaction of customary closing conditions. Grünenthal will finance the transaction using available liquidity.

User Name	Rating (out of 5)	Favorite Aspect	Common Complaint	Recommended?
John D.	4.5	Quick onset	Slight headache	Yes
Lisa S.	4.0	Long duration of effect	Mild dizziness	Yes
Amir K.	3.5	Natural ingredients	Price slightly high	Maybe
Maria L.	4.2	No significant side-effects	None reported	Yes

The financial terms of the transaction are not disclosed. Cialis® is indicated for the oral treatment of erectile dysfunction and signs and symptoms of benign prostatic hyperplasia in adult men1.

1.1 Erectile Dysfunction

Phi Lambda Sigma

Cialis® is indicated for the oral treatment of erectile dysfunction and signs and symptoms of benign prostatic hyperplasia in adult men1. The acquisition will expand Grünenthal's Latin American Men's Health product portfolio. "Executing on our strategy of targeted acquisitions, Cialis® will expand our existing portfolio in the region and strengthen Grünenthal's Latin American business", says Gabriel Baertschi, CEO, Grünenthal. "In 2022, we acquired Nebido®, a long-acting treatment for testosterone deficiency, and with Cialis® we can continue to serve our existing customer base and foster our growth in key Latin American markets." Through the acquisition of Cialis®, Grünenthal continues executing its strategy of acquiring established medicines to expand its portfolio and increase its profitability. Since 2017, Grünenthal has invested over €2 billion in the acquisition of established medicines, including Nebido®, the European rights to Crestor® and Nexium®, as well as the global rights to Vimovo® (excluding the U.S.

TUFTS Clinical Trial Material Round Table

and Japan), Qutenza® and Zomig® (excluding Japan). In 2023, Grünenthal established Grünenthal Meds, a joint venture with Kyowa Kirin International, which manages a portfolio of 13 brands primarily focused on pain management and, in 2024, acquired the US company Valinor Pharma and the product Movantik®. 1 In Mexico Cialis® is indicated for the oral treatment of erectile dysfunction and symptoms of benign prostatic hyperplasia in adult men. About Grünenthal Grünenthal is a global leader in pain management and related diseases. As a science-based, fully integrated pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. The acquisition will expand Grünenthal's Latin American Men's Health product portfolio.

Product	Dosage	Quantity + Bonus	Price
Cialis Professional	40mg	60 + 2 Pills	262.32€ 249.83€
Cialis Generic	5mg	10 Pills	29.39€ 27.99€
Cialis Generic	2.5mg	270 + 10 Pills	199.64€ 190.13€
Cialis Soft Tabs	20mg	120 + 6 Pills	248.64€ 236.80€
Cialis Generic	10mg	360 + 10 Pills	388.49€ 369.99€
Cialis Original	20mg	48 + 4 Pills	224.69€ 213.99€
Cialis Soft Tabs	20mg	270 + 10 Pills	471.40€ 448.95€
Cialis Generic	5mg	120 + 6 Pills	132.92€ 126.59€
Cialis Generic	2.5mg	360 + 10 Pills	260.03€ 247.65€
Cialis Black	80mg	180 + 10 Pills	356.64€ 339.66€
Cialis Professional	20mg	20 Pills	78.33€ 74.60€
Cialis Professional	40mg	20 Pills	110.24€ 104.99€
Cialis Generic	20mg	120 + 8 Pills	188.15€ 179.19€
Cialis Soft Tabs	20mg	30 + 4 Pills	87.43€ 83.27€
Cialis Super Active	20mg	270 + 30 Pills	661.49€ 629.99€
Cialis Generic	60mg	360 + 10 Pills	570.52€ 543.35€

"Executing on our strategy of targeted acquisitions, Cialis® will expand our existing portfolio in the region and strengthen Grünenthal's Latin American business", says Gabriel Baertschi, CEO, Grünenthal. "In 2022, we acquired Nebido®, a long-acting treatment for testosterone deficiency, and with Cialis® we can continue to serve our existing customer base and foster our growth in key Latin American markets." Through the acquisition of Cialis®, Grünenthal continues executing its strategy of acquiring established medicines to expand its portfolio and increase its profitability. Since 2017, Grünenthal has invested over €2 billion in the acquisition of established medicines, including Nebido®, the European rights to Crestor® and Nexium®, as well as the global rights to Vimovo® (excluding the U.S. and Japan), Qutenza® and Zomig® (excluding Japan). In 2023, Grünenthal established Grünenthal Meds, a joint venture with Kyowa Kirin International, which manages a portfolio of 13 brands primarily focused on pain management and, in 2024, acquired the US company Valinor Pharma and the product Movantik®.

Cialis is FDA-approved for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH).
For BPH, it helps relax prostate and bladder muscles to improve urine flow.
It can be prescribed for both conditions simultaneously (ED+BPH).
The starting dose for daily BPH treatment is typically 5 mg.
Clinical trials showed significant improvement in BPH symptoms.
It is not approved for use in women or children.
Off-label uses exist but are not officially recommended by Lilly.

1 In Mexico Cialis® is indicated for the oral treatment of erectile dysfunction and symptoms of benign prostatic hyperplasia in adult men. About Grünenthal Grünenthal is a global leader in pain management and related diseases. As a science-based, fully integrated pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We focus all our activities and efforts on working towards our vision of a World Free of Pain. Grünenthal is headquartered in Aachen, Germany, and has affiliates in 28 countries across Europe, Latin America, and the U.S. Our products are available in approx.

5.3 Prolonged Erection

are safe and effective. Counterfeit versions of Cialis can be identified by the following differences on the label of the bottle when compared to the authentic product. lists “AUSTR81137” on the front of the bottle; does not include an NDC number on the front of the bottle, such as “NDC 0002-4462-30” for the 20 mg tablets; does not include the tablet strength in a colored box; has different patterns and colors; it has yellow and darker green designs on the front label; has misspellings; it lists, “CLALIS is a product of: Eli lilly Australia PTY Limited” on the side of the bottle; lists the manufacturer location as “112 Wharf Road, WEST RYDE, NSW 2114” on the side of the bottle; and lists “Lot: AC 066018, Exp: 01SEP17” on the side of the bottle. Consumers should not use products that match one or more of the descriptions above. If you have additional information about these products, you may contact FDA at DrugSupplyChainIntegrity@fda.hhs.gov.

More FAQ

To date, FDA is not aware of consumer adverse events related to the use of these counterfeit versions of Cialis. Health care professionals and consumers are encouraged to report adverse events related to the use of any suspect medications to FDA’s MedWatch Adverse Event Reporting program by: Completing and submitting the report online at MedWatch Online Voluntary Reporting Form Downloading and completing the form (PDF - 1.22MB), then submitting it via fax at 1-800-FDA-0178 Consumers who buy prescription medicines online should be careful. Some websites sell medicine that may not be safe to use and may put their health at risk. Go to for more information about the risks, to learn the signs of websites that may sell counterfeit or otherwise unsafe medicines, and how to find legitimate licensed online pharmacies. FDA is committed to protecting public health by working to secure the drug supply chain against counterfeit and unapproved medications that enter the United States through fraudulent sources.

Customer Relationship Individual Leadership Award

Picture of authentic bottle of Eli Lilly’s Cialis 20 mg Tablets sold in the U.S. Once you dig into the Cialis vs Tadalafil debate, you’ll discover that they have a great deal in common — and that their key differences are largely cosmetic and commercial in nature. For starters, Tadalafil and Cialis have the same active ingredient: Tadalafil. In a lab test, you’d expect them to react the same way and produce indistinguishable results. And when you take either Cialis or Tadalafil, your body will be reacting to the same chemicals. In 2024, Grünenthal employed around 4,300 people and achieved revenues of €1.8 billion. Follow us on: LinkedIn: Grunenthal Group Instagram: grunenthal Click here for our Grünenthal Report 2024/2025 Grünenthal announces acquisition of the rights to Cialis® from Lilly in Mexico, Brazil & Colombia (pdf, 137.3 KB) Singapore, 5 February 2024 Zuellig Pharma, a leading healthcare solutions company in Asia, has announced that it has completed the acquisition of two brands, Cialis® (Tadalafil) and Alimta® (Pemetrexed), from Eli Lilly and Company (“Lilly”) for select ASEAN markets, including Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines and Thailand, via its wholly-owned subsidiary, Zanovex Pte. Zanovex will own the trademarks and marketing authorisations, and license manufacturing know-how for Alimta®, an established chemotherapy drug for the treatment of a certain type of non-small cell lung cancer and malignant pleural mesothelioma, and Cialis®, a leading men’s health product for the treatment of erectile dysfunction.

Comparisons are often made between Cialis (tadalafil) and Viagra (sildenafil).
Cialis has a much longer duration of action (36 vs. 4-6 hours).
Viagra's effects can be more impaired by a high-fat meal.
Cialis daily dosing offers constant coverage, unlike Viagra.
Some patients report different side effect profiles between the drugs.
The choice depends on individual patient needs, lifestyle, and response.
A healthcare provider can help determine the most suitable option.

ZP Therapeutics, the commercial division of Zuellig Pharma, will promote the two brands in the relevant markets. Prior to the acquisition, ZP Therapeutics was responsible for the promotion and distribution of the brands as part of a broader, long-term strategic partnership with Lilly in Brunei, Indonesia, Malaysia, Philippines and Thailand. “This acquisition marks a major milestone in the evolution of Zuellig Pharma to becoming an integrated healthcare solutions company.

Myths and misconceptions about Cialis are common.
Myth: It guarantees an erection every time. (Reality: Stimulation needed.)
Myth: It cures erectile dysfunction. (Reality: It's a treatment, not a cure.)
Myth: Larger doses work better for everyone. (Reality: Dose is individualized.)
Myth: It protects against STDs or pregnancy. (Reality: It does not.)
Myth: It's safe to buy without a prescription online. (Reality: It's risky.)
Always rely on information from a healthcare professional.

5.5 Sudden Hearing Loss

While this shipment was stopped, FDA is concerned about other possible mail shipments to consumers. FDA laboratory analysis showed the counterfeit versions contain multiple active ingredients, which if used could result in adverse effects or harm. Consumers should 20 cialis only buy prescription medicines from state-licensed pharmacies located in the U.S. FDA cannot confirm that the manufacturing, quality, storage, and handling of these products follow U.S. standards because these products are from an unknown source. Therefore, these products are considered unsafe and should not be used. FDA also recommends consumers talk to their health care professional about their condition and options for treatment if they received a counterfeit product. FDA-approved Cialis tablets made by Eli Lilly contain the active ingredient, tadalafil, and are used for the treatment of erectile dysfunction and other approved indications.

17.8 Sudden Hearing Loss

Our people serve more than 200,000 medical facilities and work with over 450 clients, including the top 20 pharmaceutical companies in the world. ZP Therapeutics, a division of Zuellig Pharma, is the commercialisation partner of choice for the healthcare industry with offices in 13 countries across Asia and over 2,500 associates. A catalyst in improving patient journeys and healthcare outcomes through commercial excellence, robust in-market capabilities and strong ethical principles, ZP Therapeutics is a trusted partner for expanding patient access and providing innovations to the healthcare community. FDA is alerting consumers and health care professionals that counterfeit versions of Cialis 20 mg tablets were found in the mail on its way to a U.S. consumer.

International Society for Pharmaceutical Engineering (ISPE)

Benign prostatic hyperplasia

Therefore, these products are considered unsafe and should not be used. FDA also recommends consumers talk to their health care professional about their condition and options for treatment if they received a counterfeit product. FDA-approved Cialis tablets made by Eli Lilly contain the active ingredient, tadalafil, and are used for the treatment of erectile dysfunction and other approved indications. Currently, Eli Lilly’s authentic product is considered safe and effective for its intended uses. There is no indication that the legitimate supply chain is at risk, therefore consumers can be confident that prescription medicines received through legitimate state-licensed pharmacies located in the U.S. Currently, Eli Lilly’s authentic product is considered safe and effective for its intended uses. There is no indication that the legitimate supply chain is at risk, therefore consumers can be confident that prescription medicines received through legitimate state-licensed pharmacies located in the U.S.

Step	Description	Notes
Take dose as directed	1 tablet per day or as prescribed	Follow medical advice
Time to effect	30-60 minutes after ingestion	Varies individually
Duration of effect	Up to 36 hours	Longer-lasting than some alternatives
Avoid alcohol	Alcohol can decrease effectiveness and increase side effects	Limit intake during use

are safe and effective.

7.2 Potential for Other Drugs to Affect CIALIS

Our purpose is to change lives for the better – and innovation is our passion. We focus all our activities and efforts on working towards our vision of a World Free of Pain. Grünenthal is headquartered in Aachen, Germany, and has affiliates in 28 countries across Europe, Latin America, and the U.S. Our products are available in approx. In 2024, Grünenthal employed around 4,300 people and achieved revenues of €1.8 billion.

Tadalafil and insulin sensitivity: why it matters for muscle gain

Follow us on: LinkedIn: Grunenthal Group Instagram: grunenthal Click here for our Grünenthal Report 2024/2025 Grünenthal announces acquisition of the rights to Cialis® from Lilly in Mexico, Brazil & Colombia (pdf, 137.3 KB) Singapore, 5 February 2024 Zuellig Pharma, a leading healthcare solutions company in Asia, has announced that it has completed the acquisition of two brands, Cialis® (Tadalafil) and Alimta® (Pemetrexed), from Eli Lilly and Company (“Lilly”) for select ASEAN markets, including Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines and Thailand, via its wholly-owned subsidiary, Zanovex Pte. Zanovex will own the trademarks and marketing authorisations, and license manufacturing know-how for Alimta®, an established chemotherapy drug for the treatment of a certain type of non-small cell lung cancer and malignant pleural mesothelioma, and Cialis®, a leading men’s health product for the treatment of erectile dysfunction. ZP Therapeutics, the commercial division of Zuellig Pharma, will promote the two brands in the relevant markets. Prior to the acquisition, ZP Therapeutics was responsible for the promotion and distribution of the brands as part of a broader, long-term strategic partnership with Lilly in Brunei, Indonesia, Malaysia, Philippines and Thailand. “This acquisition marks a major milestone in the evolution of Zuellig Pharma to becoming an integrated healthcare solutions company.

Rho Chi

It demonstrates the increasing strength of ZP Therapeutics, which has extensive in-market expertise and capabilities in driving growth of healthcare products in Asia. We look forward to further expanding our commercial presence in the region through meaningful strategic partnerships with the world’s leading biopharma companies as we remain focused on our purpose of making healthcare more accessible to communities in Asia,” said John Graham, Group CEO, Zuellig Pharma. Zuellig Pharma is a leading healthcare solutions company in Asia, and our mission is to make healthcare more accessible to the communities we serve. We provide world-class distribution, digital and commercial services to support the growing healthcare needs in this region. The company was started a hundred years ago and has grown to become a multibillion-dollar business covering 16 markets with over 12,000 employees. Counterfeit versions of Cialis can be identified by the following differences on the label of the bottle when compared to the authentic product. lists “AUSTR81137” on the front of the bottle; does not include an NDC number on the front of the bottle, such as “NDC 0002-4462-30” for the 20 mg tablets; does not include the tablet strength in a colored box; has different patterns and colors; it has yellow and darker green designs on the front label; has misspellings; it lists, “CLALIS is a product of: Eli lilly Australia PTY Limited” on the side of the bottle; lists the manufacturer location as “112 Wharf Road, WEST RYDE, NSW 2114” on the side of the bottle; and lists “Lot: AC 066018, Exp: 01SEP17” on the side of the bottle. Consumers should not use products that match one or more of the descriptions above. If you have additional information about these products, you may contact FDA at DrugSupplyChainIntegrity@fda.hhs.gov. To date, FDA is not aware of consumer adverse events related to the use of these counterfeit versions of Cialis. Health care professionals and consumers are encouraged to report adverse events related to the use of any suspect medications to FDA’s MedWatch Adverse Event Reporting program by: Completing and submitting the report online at MedWatch Online Voluntary Reporting Form Downloading and completing the form (PDF - 1.22MB), then submitting it via fax at 1-800-FDA-0178 Consumers who buy prescription medicines online should be careful. Some websites sell medicine that may not be safe to use and may put their health at risk. Go to for more information about the risks, to learn the signs of websites that may sell counterfeit or otherwise unsafe medicines, and how to find legitimate licensed online pharmacies. FDA is committed to protecting public health by working to secure the drug supply chain against counterfeit and unapproved medications that enter the United States through fraudulent sources. Picture of authentic bottle of Eli Lilly’s Cialis 20 mg Tablets sold in the U.S. Once you dig into the Cialis vs Tadalafil debate, you’ll discover that they have a great deal in common — and that their key differences are largely cosmetic and commercial in nature.

2.4 CIALIS for Once Daily Use for Erectile Dysfunction and Benign Prostatic Hyperplasia

They’ll produce the same physical responses by the same mechanism to help you gain an erection and maintain it for a longer period of time. Put simply, the biggest distinction between Cialis and Tadalafil is the box it comes in and how much you pay for it. Cialis is a brand name product whereas Tadalafil is generic – although it has the same active content and effects. For starters, Tadalafil and Cialis have the same active ingredient: Tadalafil. In a lab test, you’d expect them to react the same way and produce indistinguishable results. And when you take either Cialis or Tadalafil, your body will be reacting to the same chemicals. They’ll produce the same physical responses by the same mechanism to help you gain an erection and maintain it for a longer period of time. Put simply, the biggest distinction between Cialis and Tadalafil is the box it comes in and how much you pay for it. Cialis is a brand name product whereas Tadalafil is generic – although it has the same active content and effects.

Research and development continue beyond the original Cialis patent.
Studies have investigated tadalafil for other conditions like Raynaud's.
Its use in pulmonary hypertension is approved under the name Adcirca.
Research into new formulations or delivery methods is ongoing.
The understanding of PDE5 inhibitors' long-term effects continues to evolve.
Lilly and other companies invest in next-generation erectile dysfunction treatments.
The legacy of Cialis has shaped the entire ED treatment landscape.