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Sildenafil tablets are indicated for the treatment of pulmonary arterial hypertension (WHO Group I) in adults to improve exercise ability and delay clinical worsening. The delay in buy sildenafil uk clinical worsening was demonstrated when sildenafil tablets were added to background epoprostenol therapy [see Clinical Studies (14)].

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Vasodilation effects may be more common in patients with hypotension or on antihypertensive therapy. Use in pulmonary veno-occlusive disease may cause pulmonary edema and is not recommended. Hearing or visual impairment: Seek medical attention if sudden decrease or loss of vision or hearing occurs. Pulmonary hypertension secondary to sickle cell disease: Sildenafil citrate may cause sildenafil gel serious vaso-occlusive crises. Most common adverse reactions greater than or equal to 3% and more frequent than placebo were epistaxis, headache, dyspepsia, flushing, insomnia, erythema, dyspnea, and rhinitis.

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To report SUSPECTED ADVERSE REACTIONS, contact AvKARE, Inc. at 1-855-361-3993 or FDA at 1-800-FDA-1088 or See 17 for PATIENT COUNSELING INFORMATION and FDA-approved patient labeling. Table of Contents FULL PRESCRIBING INFORMATION: CONTENTS*RECENT MAJOR CHANGES1 INDICATIONS AND USAGE2 DOSAGE AND ADMINISTRATION2.1 Sildenafil Tablets3 DOSAGE FORMS AND STRENGTHS4 CONTRAINDICATIONS5 WARNINGS AND PRECAUTIONS5.1 Hypotension5.2 Worsening Pulmonary Vascular Occlusive Disease5.3 Epistaxis5.4 Visual Loss5.5 Hearing Loss5.6 Combination with other PDE-5 Inhibitors5.7 Priapism5.8 Vaso-occlusive Crisis in Patients with Pulmonary Hypertension Secondary to Sickle Cell Anemia6 ADVERSE REACTIONS6.1 Clinical Trials Experience6.2 Postmarketing Experience7 DRUG INTERACTIONS8 USE IN SPECIFIC POPULATIONS8.1 Pregnancy8.2 Lactation8.4 Pediatric Use8.5 Geriatric Use8.6 Patients with Hepatic Impairment8.7 Patients with Renal Impairment10 OVERDOSAGE11 DESCRIPTION12 CLINICAL PHARMACOLOGY12.1 Mechanism of Action12.2 Pharmacodynamics12.3 Pharmacokinetics13 NONCLINICAL TOXICOLOGY13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility14 CLINICAL STUDIES16 HOW SUPPLIED/STORAGE AND HANDLING17 PATIENT COUNSELING INFORMATION*Sections or subsections omitted from the full prescribing information are not listed. 1 INDICATIONS AND USAGE Sildenafil tablets are indicated for the treatment of pulmonary arterial hypertension (WHO Group I) in adults to improve exercise ability and delay clinical worsening. The delay in clinical worsening was demonstrated when sildenafil tablets were added to background epoprostenol therapy [see Clinical Studies (14)].Studies establishing effectiveness were short-term (12 to 16 weeks), and included predominately patients with New York Heart Association (NYHA) Functional Class II-III symptoms and idiopathic etiology (71%) or associated with connective tissue disease (CTD) (25%). Studies establishing effectiveness were short-term (12 to 16 weeks), and included predominately patients with New York Heart Association (NYHA) Functional Class II-III symptoms and idiopathic etiology (71%) or associated with connective tissue disease (CTD) (25%).

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2 DOSAGE AND ADMINISTRATION 2.1 Sildenafil TabletsOral DosageThe recommended dosage of sildenafil tablet is 20 mg three times a day [see Clinical Studies (14)].Pediatric use information is approved for Viatris Specialty LLC’s, REVATIO (sildenafil) tablets.

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However, due to Viatris Specialty LLC’s marketing exclusivity rights, this drug product is not labeled with that information.

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All products we offer are fully registered with the Philippine FDA, ensuring you receive only authentic and high-quality medications. We do not sell unregistered or counterfeit medicines — ever. Each product undergoes verification, and you can independently confirm its FDA status. 🧾 Genuine medicines with verified FDA approval🔍 FDA Registration Number provided for transparency🔒 Trusted by thousands of Filipino customers nationwide As a fully licensed FDA distributor, Bambang Pharmaceutical Depot Inc. is authorized to sell medicines online and deliver nationwide.

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You can shop with confidence knowing you’re buying from a legal, secure, and government-accredited source. We are listed in the FDA’s Certificates and Permits section, affirming our compliance with all regulations for pharmaceutical distribution. MEDICINES We offer large range of generics and branded tablets, capsules, topicals, suppositories, drops or suspensions, inhalers and injections. We offer large range of generics and branded tablets, capsules, topicals, suppositories, drops or suspensions, inhalers and injections. SUPPLEMENTS High quality yet very affordable vitamins and minerals, specialty supplements, herbals and botanicals, sports nutrition, and weight management. Pediatric use information is approved for Viatris Specialty LLC’s, REVATIO (sildenafil) tablets. 4 CONTRAINDICATIONS Sildenafil tablets are contraindicated in patients with:Concomitant use of organic nitrates in any form, either regularly or intermittently, because of the greater risk of hypotension [see Warnings and Precautions (5.2)] .Concomitant use of riociguat, a guanylate cyclase stimulator.

  • Sildenafil 50 mg is available by prescription only.
  • It may interact with medications containing nitrates.
  • Store tablets in a cool, dry place away from children.

PDE-5 inhibitors, including sildenafil, may potentiate the hypotensive effects of riociguat.Known hypersensitivity to sildenafil or any component of the tablet. Hypersensitivity, including anaphylactic reaction, anaphylactic shock and anaphylactoid reaction, has been reported in association with the use of sildenafil. Sildenafil tablets are contraindicated in patients with: Concomitant use of organic nitrates in any form, either regularly or intermittently, because of the greater risk of hypotension [see Warnings and Precautions (5.2)] .

  • Sildenafil 50 mg may cause dizziness; avoid driving if affected.
  • Combining sildenafil with certain drugs can be dangerous; discuss with your doctor.
  • Do not use if you have severe liver or kidney disease.

PDE-5 inhibitors, including sildenafil, may potentiate the hypotensive effects of riociguat.

  • Sildenafil does not cure underlying conditions causing erectile dysfunction.
  • Use caution if you have low blood pressure or cardiovascular issues.
  • Regular check-ups can help monitor effectiveness and safety.

Known hypersensitivity to sildenafil or any component of the tablet. 5 WARNINGS AND PRECAUTIONS 5.1 HypotensionSildenafil citrate has vasodilatory properties, resulting in mild and transient decreases in blood pressure.

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(1)DOSAGE AND ADMINISTRATIONTablet: 20 mg three times a day, 4 to 6 hours apart (2.1)DOSAGE FORMS AND STRENGTHSTablets: 20 mg (3)CONTRAINDICATIONSWARNINGS AND PRECAUTIONSIncreased mortality with increasing doses in pediatric patients. Not recommended for use in pediatric patients. (5.1)Vasodilation effects may be more common in patients with hypotension or on antihypertensive therapy. (5.2)Use in pulmonary veno-occlusive disease may cause pulmonary edema and is not recommended. (5.3)Hearing or visual impairment: Seek medical attention if sudden decrease or loss of vision or hearing occurs.

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(5.5, 5.6)Pulmonary hypertension secondary to sickle cell disease: Sildenafil citrate may cause serious vaso-occlusive crises. (5.9)ADVERSE REACTIONSMost common adverse reactions greater than or equal to 3% and more frequent than placebo were epistaxis, headache, dyspepsia, flushing, insomnia, erythema, dyspnea, and rhinitis. (6.1, 6.2)To report SUSPECTED ADVERSE REACTIONS, contact AvKARE, Inc. at 1-855-361-3993 or FDA at 1-800-FDA-1088 or INTERACTIONSSee 17 for PATIENT COUNSELING INFORMATION and FDA-approved patient labeling.Revised: 10/2018 Warnings and Precautions, Visual Loss (5.5) 07/2017 Sildenafil tablets are a phosphodiesterase-5 (PDE-5) inhibitor indicated for the treatment of pulmonary arterial hypertension (PAH) (WHO Group I) in adults to improve exercise ability and delay clinical worsening. Tablet: 20 mg three times a day, 4 to 6 hours apart (2.1) Increased mortality with increasing doses in pediatric patients. Before prescribing sildenafil citrate, carefully consider whether patients with certain underlying conditions could be adversely affected by such vasodilatory effects (e.g., patients on antihypertensive therapy or with resting hypotension [BP less than 90/50], fluid depletion, severe left ventricular outflow obstruction, or autonomic dysfunction).

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High quality yet very affordable vitamins and minerals, specialty supplements, herbals and botanicals, sports nutrition, and weight management. MEDICAL SUPPLIES We serve all types of medical supplies needed in clinics, laboratories, and hospitals like cottons, gauze, alcohol, swabs, gloves, bandages, lancets, glucometer, etc. We serve all types of medical supplies needed in clinics, laboratories, and hospitals like cottons, gauze, alcohol, swabs, gloves, bandages, lancets, glucometer, etc. MEDICAL EQUIPMENT We also serve durable and affordable medical devices and equipment needed in clinics, laboratories and hospitals. We also serve durable and affordable medical devices and equipment needed in clinics, laboratories and hospitals.

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HIGHLIGHTS OF PRESCRIBING INFORMATION Sildenafil Tablets, USPRx OnlyThese highlights do not include all the information needed to use SILDENAFIL TABLETS safely and effectively. See full prescribing information for SILDENAFIL TABLETS.SILDENAFIL tablets, for oral useInitial U.S. Approval: 1998RECENT MAJOR CHANGESWarnings and Precautions, Visual Loss (5.5) 07/2017INDICATIONS AND USAGESildenafil tablets are a phosphodiesterase-5 (PDE-5) inhibitor indicated for the treatment of pulmonary arterial hypertension (PAH) (WHO Group I) in adults to improve exercise ability and delay clinical worsening. Studies establishing effectiveness were short-term (12 to 16 weeks), and included predominately patients with NYHA Functional Class II-III symptoms. Etiologies were idiopathic (71%) or associated oral sildenafil with connective tissue disease (25%). Monitor blood pressure when co-administering blood pressure lowering drugs with sildenafil citrate.5.2 Worsening Pulmonary Vascular Occlusive DiseasePulmonary vasodilators may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease (PVOD). Since there are no clinical data on administration of sildenafil citrate to patients with veno-occlusive disease, administration of sildenafil citrate to such patients is not recommended. Should signs of pulmonary edema occur when sildenafil citrate is administered, consider the possibility of associated PVOD.5.3 EpistaxisThe incidence of epistaxis was 13% in patients taking sildenafil citrate with PAH secondary to CTD.

  • Sildenafil 50 mg is a generic medication; brand names may vary.
  • Overuse can lead to priapism, a painful prolonged erection.
  • Communicate openly with your healthcare provider about your health status.